A study of drug-drug interactions between voriconazole and omeprazole in combination

ZHANG Yuan; ZHU Li-qin; QI Fang; ZHOU Xiu-jie

Abstract：Objective:To establish the drug-drug interactions model between voriconazole and omeprazole and explore the influence of the pharmacokinetics when co-administered with each other,and to provide theoretical reference for the rational use of drugs in the clinical practices.Methods:The physicochemical properties parameter,in vitro parameters and pharmacokinetic data of voriconazole and omeprazole were retrieved and collected.The PBPK model of voriconazole and omeprazole was respectively established and verified.Finally,the drug-drug interactions model was established on the basis of these models.Results:The drug-drug interactions model showed that omeprazole will affect the voriconazole plasma concentration,the maximum plasma concentration (Cmax),total area under the plasma concentration time curve (AUC0-inf) of voriconazole and area under the plasma concentration time curve of voriconazole at the end of the observation point (AUC0-t) were increased.The increase rates were 16.5％,38.7％ and 37.5％,respectively.Conclusion:This study showed that omeprazole can increase voriconazole plasma concentration when co-administered with voriconazole.Due to the increased blood plasma concentration of voriconazole was within the therapeutic window,the doseage adjusting of voriconazole was unnecessary when co-administered with omeprazole.