Design and optimization of thermosensitive in situ gel of 5-aminolevulinic acid hydrochloride
ZENG Ling-jun
ZHUANG Shan-shan
HUANG Ai-wen
SONG Hong-tao
Abstract：Objective:To develop thermosensitive in situ gel of 5-aminolevulinic acid hydrochloride.Methods:Appearance and gelling temperature were used as indexes to determine the optimal gel bases,moisturizer,preservative,penetration enhancer and drug concentration.The penetration enhancer was further screened with cumulative penetration amount,steady penetration rate and cumulative transmittance as the evaluation indexes.The in vitro release property was also evaluated with accumulative release rate as the evaluation index.Results:The optimum formulation composition was confirmed as follows:5％ 5-aminolevulinic acid hydrochloride,20％ poloxamer 407,4％ poloxamer 188,10％ glycerinum,0.1％ ethylparaben,1％ propylene glycol,3％ azone,with water added to 100％.The transdermal absorption of the optimum thermosensitive in situ gel of 5-aminolevulinic acid hydrochloride was better than the commercially available preparation.The accumulative release rate in 4 h of the prepared gel was up to 80％.The release property in vitro conformed to first order kinetic equation.Conclusion:The thermosensitive in situ gel of 5-aminolevulinic acid hydrochloride developed in this study showed good release property and transdermal absorption,which may become a new-type preparation of 5-aminolevulinic acid hydrochloride for photodynamic therapy.
Keywords：5-aminolevulinic acid hydrochloridein situ geltransdermal absorptionrelease in vitro
Publication Date：2017-01-01
Online Publishing Date：2026-08-14(First online date of this platform, not the publication date of the document)
Pages：6( 2485-2490 )