The effect of hyperbilirubinemia on left heart function in newborns evaluation by real-time three-dimensional echocardiography combined with tissue motion mitral annular displacement automatic tracking technology
Tao Ying
Liu Guohui
Zhou Jie
Xu Jianfang
Qi Yinjing
Ma Haiqin
Abstract：Objective Real-time three-dimensional echocardiography(RT-3DE)combined with tissue motion mitral annular displacement automatic tracking technology(TMAD)was used to evaluate relevant indicators and to explore the effect of hyperbilirubinemia on left heart function in newborns.Methods A total of ninety newborns with hyperbilirubinemia admitted to the Department of Neonatology,Inner Mongolia Maternal and Child Health Hospital from June 2022 to June 2023 were selected and divided into mild jaundice group(total bilirubin 221-255 μmol/L),moderate jaundice group(total bilirubin 256-341 μmol/L),and severe jaundice group(total bilirubin≥342 μmol/L)based on total bilirubin levels,with 30 cases in each group.Thirty healthy full-term newborns from the same period were selected as the control group.The left ventricular function of newborns in each group were evaluated by collecting relevant parameters such as RT-3DE and TMAD,and the correlation between each parameter and the left ventricular ejection fraction(LVEF)of the newborns were explored.Results The mitral valve E peak flow velocity,peak E to peak A velocity ratio,LVEF,left ventricular end diastolic volume,mitral annulus interventricular annular displacement(TMAD AP4 MV1),left ventricular sidewall annular displacement(TMAD AP4 MV2),mean midpoint displacement of the mitral annulus line during systole(TMAD Midpt),and mean midpoint displacement rate of the mitral annulus(TMAD Midpt％)in the severe jaundice group were all lower than those in the other groups,while the mitral valve A peak flow velocity and left atrial ejection fraction of the mitral orifice were higher than those in the other groups(all P＜0.05).TMAD AP4 MV1,TMAD AP4 MV2,TMAD Midpt,and TMAD Midpt％were all positively correlated with LVEF(r=0.823,0.758,0.727,0.842,all P=0.001),among which TMAD Midpt％showed the best correlation.Conclusion Hyperbilirubinemia to a certain extent can affect the left heart function of newborns.RT-3DE combined with TMAD can early evaluate left heart function in newborns,and its measurement indicators have a good correlation with LVEF of the newborns.
Keywords：HyperbilirubinemiaReal-time three-dimensional ultrasoundNewbornsLeft heart function
Publication Date：2025-04-18
Online Publishing Date：2026-09-14(First online date of this platform, not the publication date of the document)
Pages：5( 582-586 )