DOI: 10.1002/ame2.70076
Advances in miRNA research:Unraveling the complexities of gene regulation
Jiawei Zheng
Guoqing Zhang
Linzhu Ren
College of Animal Sciences,Key Lab for Zoonoses Research,Ministry of Education,Jilin University,Changchun,China
摘要：MicroRNAs(miRNAs)are crucial in diverse biological processes.In recent years,ex-tensive research has significantly advanced our understanding of miRNA biogenesis,function,and its implications in various biological processes and diseases.In devel-opment,miRNAs precisely regulate gene expression to ensure proper organismal growth.miRNAs serve as essential modulators of cell proliferation and differentia-tion,thereby determining cell fate.Regarding the regulation of apoptosis,miRNAs play a significant role in controlling programmed cell death.Moreover,in metabolism,miRNAs are involved in modulating various pathways.This review examines the latest advancements in miRNA research,encompassing their biogenesis,functional roles,and involvement in various biological processes and diseases.A specific emphasis is placed on the roles of miRNAs in development,cell proliferation,apoptosis,and metabolic regulation.Additionally,cutting-edge technologies were discussed for the potential therapeutic applications of miRNA-based strategies.
机标关键词：researchmirnageneadvancescomplexitiesregulationunraveling
论文发表日期：2025-10-30
在线出版日期：2025-12-16（本平台首次上网日期，不代表文献的发表时间）
页数：19( 1741-1759 )
英文信息