DOI: 10.1002/ame2.70089
Animal models of hypertension and concurrent organs injury
Ye Wang
Xiaoliang Jiang
Zhiwei Yang
NHC Key Laboratory of Human Disease Comparative Medicine,Institute of Laboratory Animal Sciences(CAMS & PUMC),National Center of Technology Innovation for Animal Model,National Human Diseases Animal Model Resource Center,Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Beijing,P.R.China
摘要：Although hypertension is a frequently seen chronic condition across the world,its exact cause remains unclear.Animal models are beneficial for clarifying the patho-genic mechanism of hypertension and examining new treatments.An optimal ani-mal model for studies on hypertension must well mimic human-like hemodynamics and pathophysiological structural modification,showing human disease features and complications timely or even ahead of time.A review of the most frequently used hypertensive animal models available,including small and large animals,induced and genetic models,would provide an insight into the appropriate targets to be addressed in the development of different hypertensive animal models.Another focus of the review are the processes of target-organs injury caused by high blood pressure,which mainly influences human health.
机标关键词：hypertensionmodelsanimalconcurrentinjuryorgans
论文发表日期：2025-10-30
在线出版日期：2025-12-16（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1775-1784 )
英文信息