DOI: 10.1002/ame2.70041
Intratympanic dexamethasone microcrystals/lidocaine-loaded PLGA non-spherical microparticles for local drug delivery to the inner ear
Dongcheng Wang1
Xin Zhang1
Zhen Wang1
Cheng Ran2
Jia Hao2
Xiaobo Ma3
Minghui Wang4
Zhimin Zhou1
1.Biomedical Barriers Research Center,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin,China2.Department of Otolaryngology,Affiliate Hospital of Hebei University,Baoding,China3.Key Laboratory of Otolaryngology Head and Neck Surgery,Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Ministry of Education,Capital Medical University,Beijing,China4.Department of Otorhinolaryngology Head and Neck Surgery,Tianjin Fourth Central Hospital,Tianjin,China
摘要：Background:Sudden sensorineural hearing loss(SSNHL),often associated with tin-nitus,significantly impacts individuals' quality of life.Current treatments,such as free drugs via intravenous or intratympanic(IT)administration of dexamethasone(DEX)and lidocaine,face limitations like low bioavailability and rapid drug clearance.To address these challenges,we developed a local co-delivery system combining DEX microcrystals(DEX MCs)and lidocaine-loaded poly(lactic-co-glycolic acid)(PLGA)non-spherical microparticles(LPNMs)for sustained drug release in the inner ear.
Methods:DEX MCs and LPNMs were prepared using the traditional precipitation technique and double emulsion-solvent evaporation,respectively.After character-izing physicochemical properties and drug release kinetics,they were dispersed in sodium hyaluronate solution for IT injection,then in vivo pharmacokinetics and bio-compatibility in guinea pigs were studied.
Results:DEX MCs exhibited stable dissolution,while LPNMs provided sustained li-docaine release,reducing potential side effects.In vivo studies in guinea pigs demon-strated prolonged drug retention in the perilymph and improved pharmacokinetics.Histological evaluation confirmed the good biocompatibility of this combined delivery system,with no significant inner ear damage observed.
Conclusion:This co-delivery system can be used as a depot for delivering both DEX and lidocaine to the inner ear and offers a promising approach for the synergistic treatment of SSNHL associated with tinnitus.
机标关键词：plgadeliverydexamethasonedruginnerintratympaniclidocaineloaded
论文发表日期：2025-10-30
在线出版日期：2025-12-16（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1813-1823 )
英文信息