DOI: 10.1002/ame2.70083
Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis
Razan Alawaji1
Mohamed S.Abdel-Bakky2
Hussein M.Ali3
Miad A.Aljuhani2
Abdulaziz Arif A.Alshammari2
Hashim K.Kamal4
Maamoun M.K.Khoja5
Kholoud Alsehemi4
Mennatallah A.Korani6
Eman S.Said7
1.Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraydah,Saudi Arabia;King Salman Medical City,Al Madinah Al Munawwarah,Saudi Arabia2.Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraydah,Saudi Arabia3.Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraydah,Saudi Arabia;Faculty of Medicine,Department of Biochemistry,Al-Azhar University,Assiut,Egypt4.King Salman Medical City,Al Madinah Al Munawwarah,Saudi Arabia5.King Salman Medical City,Al Madinah Al Munawwarah,Saudi Arabia;School of Health and Life Sciences,University of Glasgow,Glasgow,UK6.Faculty of Medicine,Fayoum University,Fayoum,Egypt7.Department of Pharmacology and Toxicology,College of Pharmacy,Qassim University,Buraydah,Saudi Arabia;Faculty of Medicine,Department of Medical Pharmacology,Fayoum University,Fayoum,Egypt
摘要：Background:Acute pancreatitis(AP)is a severe inflammation of the pancreas,marked by elevated enzyme levels,cellular inflammation,and necrosis.Recent studies emphasize the critical role of inflammation in AP progression.Tirzepatide,a multi-target agonist of glucagon-like peptide-1(GLP-1)and glucose-dependent insulinotropic polypeptide(GIP)receptors,has demonstrated notable anti-inflammatory and metabolic benefits.
Methods:This study explores the therapeutic potential of Tirzepatide in pancreati-tis induced by L-arginine in rats,focusing on enzymatic markers,cytokine profiles,oxidative stress,and histological outcomes.Over 27days,rats were distributed into Control,Tirzepatide,L-Arginine,and L-Arginine+Tirzepatide groups,with the latter receiving L-Arginine to induce pancreatitis followed by Tirzepatide administration.
Results:L-Arginine significantly elevated serum amylase,lipase,and inflammatory mediators(I L-6,IL-4,and IL-10),alongside oxidative stress markers and histopathological deterioration.Conversely,the L-Arginine+Tirzepatide group exhibited reduced lipase and IL-6 levels,suppressed reactive oxygen species(ROS)generation,and enhanced anti-inflammatory cytokines IL-4 and IL-10.Histopathological analysis revealed reduced necrosis and tissue damage in the L-Arginine+Tirzepatide group compared to the L-Arginine group,indicating Tirzepatide's possible protective effects.Immunofluorescence studies further demonstrated increased p-Akt expression,supporting the role of Tirzepatide in cellular repair and recovery.
Conclusion:These findings highlight Tirzepatide's ability to mitigate pancreatic damage through antioxidant and anti-inflammatory mechanisms,underscoring its potential as a pharmacological agent for acute pancreatitis.
机标关键词：acuteassessinginflammatorymitigatingmodulatingpancreatitispotentialresponses
论文发表日期：2025-10-30
在线出版日期：2025-12-16（本平台首次上网日期，不代表文献的发表时间）
页数：12( 1876-1887 )
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