DOI: 10.1002/ame2.70096
Bilateral carotid-jugular arteriovenous graft implantation in an ovine model is safe and durable for facilitation of arteriovenous graft innovation
Matthew Schneck
Gregory Brittenham
Yi Cheng
Taylor Tran
Matthew Vuoncino
Christopher Pivetti
Aijun Wang
Mimmie Kwong
Department of Surgery,University of California Davis,Sacramento,California,USA
摘要：Over 550000 people in the U.S.require hemodialysis for management of end stage renal disease(ESRD).When anatomy restricts fistula creation,arteriovenous grafts(AVG)are implanted.AVGs have poor primary patency and high risk of infection,highlighting a need for better alternatives.Previous AVG large animal models were limited by high complication rates and short-term follow-up.This study investigates the safety and durability of an ovine bilateral carotid-jugular AVG model.Eight fe-male sheep underwent bilateral carotid-jugular AVG implantation via a single lon-gitudinal incision overlying the trachea.Ringed PTFE grafts were anastomosed in a"lazy-S"configuration to provide the laxity needed to prevent avulsion and mini-mize kinking with neck movement.Post-operatively,sheep were evaluated daily to monitor for complications.Duplex ultrasonography of the grafts was performed at regular intervals out to 6 months to evaluate patency.At 6 months,angiography and duplex was performed followed by explant for gross and histologic analysis.Technical success was achieved in 16 of 16(100％)graft implants.No major com-plications,including stroke,anastomotic disruption,infection,wound breakdown,or death occurred.Primary patency of control PTFE grafts was 75％at 6 months,paralleling reported rates in humans.Bilateral carotid-jugular AVG implantation in sheep is a safe and durable model for self-controlled long-term evaluation of AVG conduit technology.
机标关键词：innovationmodelsafearteriovenousbilateralcarotid-jugulardurablefacilitation
论文发表日期：2025-10-30
在线出版日期：2025-12-16（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1908-1914 )
英文信息