DOI: 10.1002/ame2.70087
Vitamin D-induced mechanisms in cancer prevention and therapy:Recent advances and future opportunities
D.Prasanth1
Pathan Amanulla Khan2
Jamal-E-Fatima3
Trupti Pratik Durgawale4
Falak Arjumand Siddique5
Sharuk L.Khan5
Azmath Farhana6
Uttam Prasad Panigrahy7
Mohammed Abdul Aziz shahid8
Mohammed Sayeed9
Md.Faysal10
1.Department of Pharmacology,School of Pharmacy,Cent2.Department of Pharmacy Practice,Anwar ul Uloom Col3.School of Electronic Science and Engineering,Unive4.Department of Pharmaceutical Chemistry,Krishna Ins5.Department of Pharmaceutical Chemistry,N.B.S Insti6.Department of Pharmacology,School of Pharmacy,Anur7.Faculty of Pharmaceutical Science,Assam Down Town 8.Department of Pharmacy Practice,Shadan Women's Col9.Department of Pharmacology,School of Pharmacy,Anur10.Department of Pharmacy,Faculty of Health and Life
摘要：Vitamin D,with its diverse molecular pathways and immunomodulatory proper-ties,has become a crucial tool in the prevention and treatment of various cancers.It controls angiogenesis,apoptosis,differentiation,and cellular proliferation,inhibit-ing cancer through immune surveillance,DNA repair,and tumor suppression genes.Additionally,vitamin D signaling impacts tumor growth and metastasis in various cancer types by interacting with key oncogenic pathways like Wnt/β-catenin,NF-κB,PI3K/Akt,and p53.This review demonstrates the molecular and therapeutic implica-tions of vitamin D in oncology,focusing on its potential as a safe,adjuvant treatment method.It emphasizes the role of vitamin D in epigenetic modification,its impact on tumor microenvironment,and its synergistic benefits when combined with im-mune checkpoint inhibitors and chemotherapeutic drugs.Despite promising results,genetic variations in the VDR gene continue to cause issues with bioavailability,ideal dosage,and interindividual response variability.The review also proposes future re-search on vitamin D's potentiality as a therapeutic adjuvant in various malignancies,including colorectal,prostate,and breast cancers,and suggests the development of non-calcemic vitamin D analogs and the incorporation of vitamin D-based methods into personalized oncology treatments.
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论文发表日期：2025-11-30
在线出版日期：2026-01-09（本平台首次上网日期，不代表文献的发表时间）
页数：12( 1935-1946 )
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