DOI: 10.1002/ame2.70074
The Vietnamese swine as a translational model of invasive ductal carcinoma of the breast
Claudia Elizabeth Vera-Tizatl1
Arturo Vera-Hernández1
Lorenzo Leija-Salas1
Marco Antonio Vega-López2
María del Carmen Ramírez-Estudillo2
German Isauro Garrido Fariña3
Adriana Leticia Vera-Tizatl4
1.Department of Electrical Engineering,Center for Re2.Department of Infectomics and Molecular Pathogenes3.FES Cuautitlán UNAM,Histology and Biology Laborato4.Department of Mechatronics,School of Science and E
摘要：Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is highly comparable to that of humans and is histologically indistinguishable.Leveraging these advantages through the chemical induction of carcinogenesis in this model offers a robust approach to mimic human exposure to carcinogenic compounds.
Methods:This study elaborates on a protocol for developing a representative model of MNU-induced invasive breast carcinoma in three Vietnamese swine,validated histologically and immunologically.It evaluates not only the tissue similarity with humans,but also the development of chemically induced mammary tumors in an im-munologically competent animal.Moreover,this study addresses the existing gap in histological knowledge regarding mammary tissue in the porcine model.
Results:Our findings suggest that this model encompasses the full spectrum of can-cer.It incorporates the key elements of a tumor microenvironment that enable tumor growth and propagation,such as immune cells,blood vessels,fibroblasts,extracellular matrix,fatty acids,and signaling molecules.
Conclusions:This model offers significant potential to advance the understanding of cancer pathogenesis and facilitate the development of innovative therapeutic strate-gies by closely replicating human tumor biology.
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论文发表日期：2025-11-30
在线出版日期：2026-01-09（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1997-2007 )
英文信息