DOI: 10.1002/ame2.70081
Innovative insights into the effects of a high-sucrose diet on pancreatic health and the therapeutic role of empagliflozin in type 2 diabetes:An experimental study
Emad Gholami1
Ali Fardin2
Fazeleh Iranshahi2
Alireza Malek2
Ali Saravani2
Faranaz Aghvami2
Houman Parsaei3
Habib Yaribeygi1
1.Research Center of Physiology,Semnan University of2.Student Research Committee,Semnan University of Me3.Nervous System Stem Cells Research Center,Semnan U
摘要：Type 2 Diabetes(T2D)is a growing global health issue,often aggravated by excessive sugar intake.Chronic high-sucrose diets contribute to insulin resistance,oxidative stress,and pancreatic dysfunction,worsening metabolic health.Sodium-glucose co-transporter 2(SGLT2)inhibitors,like empagliflozin,show potential in improving glycemic control and metabolic parameters,but their effects on pancreatic efficiency in sugar-induced T2D are not well understood.This study aimed to explore the effects of empagliflozin on metabolic and pancreatic protection in a high-sucrose diet-induced T2D model.Male Wistar rats were divided into four groups:normal,normal-treated,diabetic,and diabetic-treated(n=8 per group).Diabetes was induced with a 35％sucrose solution for 8 weeks,followed by a low-dose streptozotocin(STZ)injection.Treated groups received empagliflozin(15 mg/kg/day)for the duration.Biochemical markers,including fasting blood sugar(FBS),lipid profile,insulin levels,and oxidative stress markers,were measured.Insulin resistance(HOMA-IR)and pancreatic function(HOMA-B)were assessed.Histological analysis of pancreatic tissues was performed.The high-sucrose diet increased FBS,insulin resistance,and oxidative stress,while decreasing pancreatic function and islet diameter.Empagliflozin treatment lowered FBS(p=0.001),improved insulin sensitivity(p=0.001),reduced triglycerides(p=0.001),and LDL(p=0.05).It also enhanced antioxidant enzymes,reduced lipid peroxidation(MDA,p=0.001),and preserved pancreatic islet structure(p=0.001).A high-sucrose diet negatively affects metabolic health and pancreatic function.Empagliflozin mitigates these effects by improving metabolism,reducing oxidative stress,and preserving pancreatic integrity,suggesting its potential as a therapeutic agent in diabetes related to excessive sugar consumption.
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论文发表日期：2025-11-30
在线出版日期：2026-01-09（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2091-2098 )
英文信息