DOI: 10.1002/ame2.70017
Comparison of the effects of metformin,citral,Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats
Milad Faraji1
Mohammad Foad Noorbakhsh1
Nasrin Kazemipour1
Saeed Nazifi2
Hamid Reza Moradi1
Nasrollah Ahmadi3
Maryam Azadmanesh1
1.Department of Basic Sciences,School of Veterinary Medicine,Shiraz University,Shiraz,Iran2.Department of Clinical Sciences,School of Veterinary Medicine,Shiraz University,Shiraz,Iran3.Department of Pathobiology,School of Veterinary Medicine,Shiraz University,Shiraz,Ira
摘要：Background:Diabetes,a metabolic disease marked by endocrine dysfunctions,signif-icantly impacts oxidative stress pathways.This study explores the protective effects of lemongrass extract(LE),citral,and lemongrass extract-synthesized silver nanopar-ticles(LE-AgNP)against hyperglycemia-induced oxidative stress by modulating the Nrf2 pathway,which is crucial for antioxidant responses.
Methods:Various techniques characterized the nanoparticles,including ultravio-let-visible spectroscopy,dynamic light scattering,zeta potential analysis,Fourier-transform infrared spectroscopy,scanning electron microscopy and transmission electron microscopy.Seventy rats,divided into seven groups,were used for in vivo experiments.Type 2 diabetes was induced using streptozotocin(65 mg/kg)and nicoti-namide(90mg/kg).After six weeks,biochemical parameters such as total antioxidant capacity,malondialdehyde,Nrf2,and Nrf2 miRNA were evaluated in pancreas tissue and blood serum,along with serum blood glucose levels.
Results:LE-AgNP significantly improved weight gain,reduced food and water intake,and lowered blood glucose levels in diabetic rats.LE and citral did not significantly alter these parameters but prevented the decline in Nrf2 gene expression.LE-AgNP showed a significant increase in Nrf2 gene expression compared to the diabetic con-trol group.
Conclusions:This study highlights the potential of LE,citral,and especially LE-AgNP in mitigating oxidative stress induced by diabetes.LE-AgNP demonstrated superior therapeutic benefits,including improved oxidative stress conditions and hypoglyce-mic effects.
机标关键词：metforminsilverstresslevelsratscitralcitratuscomparison
论文发表日期：2025-12-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：11( 2128-2138 )
英文信息