DOI: 10.1002/ame2.70092
Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus
Ifrah I.Ali1
Crystal D'Souza1
Abderrahim Nemmar2
Shreesh Ojha3
Ernest A.Adeghate4
1.Department of Anatomy,College of Medicine & Health Sciences,United Arab Emirates University,AI Ain,United Arab Emirates2.Department of Physiology,College of Medicine & Health Sciences,United Arab Emirates University,AI Ain,United Arab Emirates3.Department of Pharmacology and Therapeutics,College of Medicine &Health Sciences,United Arab Emirates University,AI Ain,United Arab Emirates4.Department of Anatomy,College of Medicine & Health Sciences,United Arab Emirates University,AI Ain,United Arab Emirates;Zayed Centre for Health Sciences,United Arab Emirates University,AI Ain,United Arab Emirates
摘要：Background:Diabetes mellitus(DM),a metabolic disorder that leads to chronic hy-perglycemia,is one of the topmost global public health concerns according to the International Diabetes Federation.Adropin is a peptide hormone that is primarily in-volved in energy homeostasis,but its involvement in other biological activities such as lowering hyperlipidemia,and diminishing insulin resistance has also been reported.In this study,we aimed to explore additional effects of adropin on oxidative stress,inflammation,and cell proliferation in an animal model of type 1 DM.
Methods:To achieve our aim,normal and diabetic Wistar rats were treated with adropin(2.1μg/kg/day)for a period of 10days.Pancreatic tissue samples were collected for histo-morphological analysis and inflammation assay,while blood was collected for oxidative stress assay.
Results:Our results showed that diabetes induction stimulated cell proliferation in both exocrine and endocrine pancreas,and adropin dramatically attenuated this effect in pancreatic exocrine tissue,but not in the islet of Langerhans.In addition,adropin signifi-cantly increased glutathione reductase expression in pancreatic tissue,and augmented serum total glutathione in the diabetic rats compared to diabetic untreated rats.
Conclusion:Our study indicates the potential role of adropin in alleviating oxidative stress in DM.
机标关键词：adropinlevelsmodelcellanimaldiabetesglutathionemellitus
论文发表日期：2025-12-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：16( 2139-2154 )
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