DOI: 10.1002/ame2.70080
Insights into organelle forming RNAs:Diversity,functions and future perspectives
Meng Gong1
Xiangting Wang2
Xiaolin Liang1
1.Division of Life Sciences and Medicine,Department of Geriatrics,Gerontology Institute of Anhui Province,The First Affiliated Hospital,University of Science and Technology of China,Hefei,Anhui,China;The RNA Institute,University of Science and Technology of China,Hefei,Anhui,China;Division of Biomedical Sciences,MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics,Hefei National Science Center for Physical Sciences at Microscale,School of Life Sciences,University of Science and Technology of China,Hefei,Anhui,China2.Division of Life Sciences and Medicine,Department of Geriatrics,Gerontology Institute of Anhui Province,The First Affiliated Hospital,University of Science and Technology of China,Hefei,Anhui,China;The RNA Institute,University of Science and Technology of China,Hefei,Anhui,China;Division of Biomedical Sciences,MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics,Hefei National Science Center for Physical Sciences at Microscale,School of Life Sciences,University of Science and Technology of China,Hefei,Anhui,China;Centre for Leading Medicine and Advanced Technologies of IHM,University of Science and Technology of China,Hefei,Anhui,China
摘要：RNA molecules play diverse and essential roles in cellular processes beyond their well-known functions in gene expression and regulation.While ribosomal RNAs(rRNAs)have long been recognized as structural components of ribosomes,recent research has highlighted the importance of a distinct group of RNAs which directly compose the structures or organelles in mammalian cells.We refer to these as'organelle for-mation RNAs'.Specifically,the discovery of tubulin-associated lncRNA(TubAR),the first identified cytoskeleton-forming RNA,has expanded our understanding of RNA functionality;we now recognize'organelle formation RNAs'not only as regulatory molecules but also as direct structural components within cellular subunits.Other'or-ganelle formation RNAs'include paraspeckle-forming RNAs,nuclear speckle-forming RNAs,and nucleolus-forming RNAs.Various RNAs contribute to the formation of distinct cellular structures,while also participating in intricate intermolecular interac-tions.Understanding these molecules not only uncovers their fundamental roles in cellular physiology but also suggests potential applications in the treatment of related diseases.By examining the latest advancements and methodologies in organelle for-mation RNA research,this review provides a comprehensive overview of the intricate mechanisms of these RNAs and future directions in the field.
机标关键词：diversityinsightsfuturernasformingfunctionsintoorganelle
论文发表日期：2025-12-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：9( 2187-2195 )
英文信息