DOI: 10.1002/ame2.70119
Multimorbidity and animal models
Xinpei Wang1
Yakun Ren1
Xingjiu Yang1
Mengyuan Li1
Junxiu Liu2
Xiaoyan Du3
Wen Wang1
Ran Gao1
1.State Key Laboratory of Respiratory Health and Multimorbidity & Institute of Laboratory Animal Science,CAMS &PUMC,Beijing,China;National Human Diseases Animal Model Resource Center,National Center of Technology Innovation for Animal Model,Institute of Laboratory Animal Science,CAMS & PUMC,Beijing,China;NHC Key Laboratory of Comparative Medicine,CAMS & PUMC,Beijing,China2.Department of Population Health Science and Policy,Icahn School of Medicine at Mount Sinai,New York,New York,USA3.The Department of Laboratory Animal Science,School of Basic Medical Science,Capital Medical University,Beijing,China
摘要：Multimorbidity-the co-occurrence of more than two chronic conditions in the same individual—is associated with premature death,diminished function,reduced quality of life,and increased societal burden.This complex state involves dynamic interac-tions across multiple conditions,organ systems,and physiological pathways;yet re-search progress remains constrained by inadequate animal models that recapitulate human complexity.This review summarizes the predominant patterns of multimorbid-ity and evaluates current animal models spanning invertebrates,rodents,and large mammals.While no single model fully captures the multifaceted nature of human multimorbidity,we propose several strategic directions to address existing limitations:implementing a cross-species validation framework(from simple organisms to rodents to large mammals),standardizing protocols integrating multimodal risk factors,de-veloping advanced non-animal models,and enhancing ethical oversight.Advancing multimorbidity models is crucial for decoding disease interactions and accelerating translation of research findings into improved patients outcomes.
机标关键词：modelsanimalmultimorbidity
论文发表日期：2025-12-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：13( 2196-2208 )
英文信息