DOI: 10.1002/ame2.70114
STING deficiency promotes motor recovery in mice following brachial plexus root avulsion
Yu Peng1
Ying Zhang2
Shenhui Yang3
Lu He3
Shuangxi Chen1
1.Department of Neurology,Multi-Omics Research Center for Brain Disorders,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan,China;Clinical Research Center for Immune-Related Encephalopathy of Hunan Province(The First Affiliated Hospital),Hengyang Medical School,University of South China,Hengyang,Hunan,China2.Institute of Pharmacy and Pharmacology,Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research,Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,University of South China,Hengyang,Hunan,China3.Department of Neurosurgery,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,Hunan,China
摘要：Background:Brachial plexus root avulsion(BPRA),a well-known form of peripheral nerve injury,results in motor function loss in the affected forelimb due to motoneu-ron(MN)death,which may be influenced by neuroinflammation following a lesion in the spinal cord.Although synthase-stimulator of interferon genes(STING)signaling can contribute to chronic inflammation and tissue damage in a number of pathologi-cal conditions,the essential role of STING signaling in BPRA remains to be reported.Based on our previous findings that the STING mRNA level is upregulated in the ante-rior horn of the segment of the affected spinal cords of mice with BPRA,STING may be associated with motor recovery in BPRA.
Methods:In the present study,STING knockout transgenic mice were used to estab-lish a BPRA re-implantation model,which was followed by behavioral tests,histo-chemical staining and quantitative reverse transcription polymerase chain reaction.
Results:The results demonstrated that STING deficiency can increase the body weight,promote motor recovery,decrease MN death,inhibit pyroptosis and neuro-inflammation,increase remyelination,and reduce the atrophy of the biceps brachii in mice with BPRA.
Conclusion:These combined results suggest that inhibition of STING may be a prom-ising strategy for treating BPRA.
机标关键词：recoveryplexusstingmotorrootmiceavulsionbrachial
论文发表日期：2025-12-30
在线出版日期：2026-03-25（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2222-2231 )
英文信息