DOI: 10.1002/ame2.70077
New approaches to treating chronic obstructive pulmonary disease with Colla corii asini
Wenchao Zhang1
Siman Sun2
Xiaoyu Fan3
Jiuming He4
Qing Li5
Hongtao Jin6
1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China2.New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;College of Pharmacy,Shaanxi University of Traditional Chinese Medicine,Xianyang,China3.New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China4.State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China5.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,China6.NMPA Key Laboratory of Safety Research and Evaluation of Innovative Drug,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;Beijing Union-Genius Pharmaceutical Technology Development Co.,Ltd.,Beijing,China
摘要：Chronic obstructive pulmonary disease(COPD)is one of the leading causes of death and disability worldwide.Its complex etiology involves factors such as smoking,air pollution,genetic susceptibility,and social environment.With the accelerating global aging population and urbanization,the incidence and burden of COPD continue to rise.Current treatment strategies for COPD are relatively conservative,primarily focusing on bronchodilators,inhaled corticosteroids,and long-term oxygen therapy.Although these approaches can alleviate symptoms and slow disease progression to some ex-tent,they fail to effectively target the underlying mechanisms of the disease,leaving an unmet clinical need for more-effective therapies.This highlights the urgency of de-veloping innovative drugs that are both safe and efficacious to address the challenges in COPD treatment.As a traditional Chinese medicine with a long history,Colla corii asini has garnered significant attention for its diverse pharmacological effects and fa-vorable safety profile.Research has shown that Colla corii asini possesses multiple bio-logical activities,including hematopoiesis,nourishing the lungs,enhancing immunity,anti-infection,antiaging,antitumor,and antifatigue effects.Moreover,it has demon-strated potential in regulating oxidative stress,immune imbalance,and inflammatory responses.Recent evidence suggests that Colla corii asini may play a protective role in lung function through multitarget and multipathway mechanisms.Based on previ-ous research findings,this paper explores the potential therapeutic value of Colla corii asini in COPD treatment by addressing the current clinical management challenges and identifying potential therapeutic targets.It also integrates the pharmacological effects of Colla corii asini into a broader treatment context,providing new perspec-tives for comprehensive COPD management and laying the theoretical foundation for its modernization and innovative application.
机标关键词：withapproachesasinichroniccollacoriidiseaseobstructive
论文发表日期：2026-01-30
在线出版日期：2026-03-27（本平台首次上网日期，不代表文献的发表时间）
页数：9( 50-58 )
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