DOI: 10.1002/ame2.70130
Challenges of modeling pristane-induced lupus in non-human primates
Elena Vladimirovna Vinogradova1
Maria Alexandrovna Varavko1
Yakov Yuryevich Ustyugov1
Alexey Alexandrovich Aleksandrov1
Dmitry Alexandrovich Khochenkov2
Yulia Nikolaevna Linkova1
1.BIOCAD,St.Petersburg,Russia2.FSBI"National Medical Research Center of Oncology named after.N.N.Blokhin"of the Ministry of Health of the Russian Federation,Moscow,Russia
摘要：A lupus-like condition induced by intraperitoneal administration of pristane(2,6,10,14-tetramethylpentadecane)in mice is widely used as a model of systemic lupus erythe-matosus(SLE).Due to their phylogenetic distance from humans,murine models are not always suitable tool for studying the specific activity of therapeutic agents and the pathogenesis of SLE.In order to overcome species-specific limitations of murine mod-els,this approach was tested in non-human primates-cynomolgus monkeys(Macaca fascicularis).Two intraperitoneal injections at a dose of 3.5mL/kg,administered at weeks 1 and 23,recapitulated SLE features,including:production of antinuclear au-toantibodies(ANA),membranoproliferative glomerulonephritis with immune complex(IC)deposition in the glomeruli.However,from week 27 five of eight pristane-treated monkeys developed progressive respiratory failure.Two of these died at week28 and the remaining were euthanized at week32.The histology of the monkey lungs sug-gested exogenous lipoid pneumonia.Thus,while pristane induced serological autoim-munity and characteristic renal manifestations in Macaca fascicularis,the consequent lipoid pneumonia limited the observation period and prevented comprehensive evalu-ation of SLE manifestations beyond 32weeks.
机标关键词：pristanemodelinglupuschallengesinducednon-humanprimates
论文发表日期：2026-02-28
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：8( 399-406 )
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