DOI: 10.1002/ame2.70103
Continuous electrocardiogram monitoring in porcine model of myocardial ischemia reperfusion
Nathaniel Hyams1
Roxanne Swagel2
Sharon Thomas2
Rupak Mukherjee3
Alicia Braxton Hickman4
Daniel Eldridge4
Kristine Helke4
Ying Mei1
Jean Marie Ruddy5
1.Department of Bioengineering,Clemson University,Clemson,South Carolina,USA2.Department of Lab Animal Resources,Medical University of South Carolina,Charleston,South Carolina,USA3.Division of Cardiothoracic Surgery,Department of Surgery,Medical University of South Carolina,Charleston,South Carolina,USA4.Department of Lab Animal Resources,Medical University of South Carolina,Charleston,South Carolina,USA;Department of Pathology,Medical University of South Carolina,Charleston,South Carolina,USA5.Division of Vascular Surgery,Department of Surgery,Medical University of South Carolina,Charleston,South Carolina,USA
摘要：As cardiovascular disease is the leading cause of global mortality,innovative animal models are vital to demonstrating the translational value of experimental discover-ies.Investigations focused on myocardial remodeling after ischemia reperfusion(I/R)are well suited to a porcine model,but the evolution of that injury and its impact on electrical conductivity or arrhythmia threshold have been difficult to monitor con-tinuously.Multiple electrode telemetry devices may be fitted to the animals but are costly and prone to damage.Implantable telemetry devices are likewise expensive,carry surgical risk,and are often verified only for single use.Here,we report the utili-zation of the commercially available Fourth Frontier X2 external telemetry device for continuous monitoring of heart rate and rhythm after myocardial I/R injury in pigs,highlighting sustained monitoring across a 7-day study.
机标关键词：ischemiatrocargrammodelcontinuousmonitoringmyocardialporcine
论文发表日期：2026-02-28
在线出版日期：2026-03-31（本平台首次上网日期，不代表文献的发表时间）
页数：5( 422-426 )
英文信息