Broad-spectrum antibacterial properties of red fluorescent car-bon quantum dots based on glucose and porphyrin ring deriva-tives
Shan Ji1
Yuhua Li1
Michelle Muxiao Wang2
Wanru Teng3
Wenming Sun3
Xin Nan1
Danlei Mou1
Xing Jin3
1.Beijing Youan Hospital,Capital Medical University,Beijing 100069,China2.Haidian Foreign Language Academy,20 Xingsikou Road,Haidian District,Beijing,China 1001953.Beijing Zhongke East Asia Nanomaterial Technology Co.,Ltd.,Beijing,China
摘要：Objectives To investigate the sterilization effects of carbon quantum dots(CDs)exhibiting red fluorescence(de-noted as SG-CDs)on various bacteria
Methods SG-CDs were prepared using a one-step high-pressure method with glucose and porphyrin ring deriva-tives as raw materials.The three antibacterial materials were SG-CDs(2000 mg/L),hypochlorous acid(2000 mg/L),and iodophor(2000 mg/L),and the five American standard bacterial strains were Staphylococcus aureus(Sau),Pseudomonas aeruginosa(Pae),Escherichia coli(Eco),Enterobacter cloacae(Ecl),and Klebsiella pneumoniae(Kpn).Each of the five bacteria was added separately to cation-adjusted Mueller-Hinton broths containing all three antibacterial ingredients and then incubated for 8 h at 35℃.After incubation,the bacteria were coated on an enrichment medium and incubated overnight at 35℃.The colony forming units in the culture medium were counted,and the sterilization effects of SG-CDs in the experimental group,positive control group,and quali-ty-control group were compared.
Results The bactericidal activity of SG-CDs against all five drug-resistant bacteria(mortality rate≥99.9%)was equivalent to that of hypochlorite but higher than that of iodophor.At the same concentration,the bactericidal activity of SG-CDs against Sau,Pae,and Eco was twice that of iodine,while the bactericidal activity of SG-CDs against Ecl and Kpn was four times that of iodine.
Conclusions In conclusion,SG-CDs showed significant bactericidal activity against five types of bacteria,name-ly Sau,Pae,Eco,Ecl,and Kpn.CDs exhibiting red fluorescence have the potential to replace antibiotics and over-come bacterial drug resistance,serving as important medicines for treating bacterial infections and wounds.
机标关键词：antibacterialfluorescentglucosequantumdotsringbasedbroad-spectrum
论文发表日期：2024-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 55-62 )
英文信息