Q fever diagnosis by metagenomic next generation sequencing:A case report
Li Qiong1
Qi Xin1
Gao Wei1
Wang Fang1
Yan Peng2
1.Department of Pulmonary and Critical Care Medicine,China Aerospace Science&Industry Corporation 731 hospital,Beijing 100074,China2.Department of Pulmonary and Critical Care Medicine,China Aerospace Science&Industry Corporation 731 hospital,Beijing 100074,China;Department of Infection Disease,China Aerospace Science&Industry Corporation 731 hospital,Beijing 100074,China
摘要：Q fever is a zoonotic infectious disease caused by the intracellular bacterial pathogen Coxiella burnetii,which of-ten manifests clinically as a fever,rash,and swollen lymph nodes.As these clinical symptoms are nonspecific,the diagnosis of Q fever is challenging.Here,we described a case of Q fever that mainly manifested as fever and pro-vide new perspectives for the diagnosis and treatment of Q fever patients.A female patient,who presented at our hospital with a fever on 3 May,2023,responded poorly to antibiotic treatment and had no clear diagnosis.Using the metagenomic next generation sequencing(mNGS)technique,the patient was diagnosed with Q fever and the symptoms were alleviated following the administration of doxycycline.In conclusion,Q fever infection is rare in clinic but its diagnosis can be aided by mNGS.Rapid diagnosis of Q fever allows for early initiation of anti-infec-tion therapy,which improves the prognosis of patients.
机标关键词：generationreportcasenextdiagnosisfevermetagenomicsequencing
论文发表日期：2024-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 63-67 )
英文信息