Research progress regarding Mycobacterium tuberculosis and its related small RNAs in the prevention and regulation of tuberculosis
Zheng Wu1
Wenjing Li2
1.Department of Science and Technology,Beijing Youan Hospital,Capital Medical University,Beijing,China2.Department of Clinical Laboratory,Tianjin First Central Hospital,Tianjin,People's Republic of China
摘要：Tuberculosis(TB),caused by Mycobacterium tuberculosis(MTB),continues to pose a significant global health challenge,particularly in developing regions.This review highlights the ability of MTB to evade host immunity and establish latent infections,which is intricately linked to its regulatory mechanisms,including small non-cod-ing RNAs(sRNAs).These sRNAs play crucial roles in modulating bacterial stress responses,metabolism,and virulence,thereby enhancing the survival of MTB in hostile environments.Recent advances in sRNA detection techniques,such as northern blotting and RT-PCR,have identified key sRNAs,including ASpks and ASdes,which appear to regulate lipid metabolism and immune evasion.Clinical studies have also suggested that sRNAs may serve as diagnostic biomarkers,potentially addressing the limitations of traditional TB diagnostic methods.De-spite these advancements,this review underscores the need for further research to fully elucidate the regulatory potential of sRNAs in TB pathogenesis and to explore their applications in diagnostics and therapy.
机标关键词：researchsmallrnasmycobacteriumpreventionprogressregardingregulation
论文发表日期：2024-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 33-41 )
英文信息