Nanoparticle drug delivery systems in solid tumor therapy
Yuan Dong1
Xuanyi Yang2
Cen Yan2
Yingmei Feng1
1.Department of Science and Technology,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China;Laboratory for Clinical Medicine,Capital Medical University,Beijing,100069,China2.Department of Science and Technology,Beijing Youan Hospital,Capital Medical University,Beijing,100069,China
摘要：Cancer is one of the leading causes of mortality that severely threatens life expectancy.Chemotherapy is the most common regimen for cancer patients.However,low drug availability in tumor site and its off-target effect elicit toxici-ty and attenuate the efficacy of chemotherapy.To overcome that,nanoparticles(NPs)have been delicately designed as carriers for tumor diagnosis and drug delivery.Being formulated and bioengineered such like chemical modification and conjugation of peptide and antibody,NPs hold distinct advantages for better biocompatibility,bioavailability and tumor cell targeting.Hereby,we first overviewed various NP formulations on cancer cell tracing and drug delivery system.Then,we performed PubMed search for NPs involved chemotherapy in clinical trials of advanced non-small-cell lung cancer(NSCLC)and breast cancer.When NPs drug system was applied for monotherapy or drug cocktail,patients were well tolerated and achieved better efficacy in most studies,as evidenced by few months of prolonged overall survival and progression-free-survival in patients among all ages.However,how to achieve long-time survival and better life quality is not covered yet.For perspectives,multimodal regimens are required to enhance targeting effi-ciency.in which NPs delivery system is synergized and integrated with pharmacological and physical treatment.
机标关键词：systemssolidtumordeliverydrugnanoparticletherapy
论文发表日期：2025-09-30
在线出版日期：2025-12-02（本平台首次上网日期，不代表文献的发表时间）
页数：24( 5-27,59 )
英文信息