Mammalian hibernation: a unique model for medical research
Xin Xing1
Shiqiang Wang2
1.College of Life Science,Shenyang Normal University,Shenyang 110034,China2.State Key Laboratory of Membrane Biology,College of Life Science,Peking University,Beijing 100871,China;Chinese Institute for Brain Research,Beijing 102206,China
摘要：Hibernation is an adaptive behavior for some small animals to survive cold winter. Hibernating mammals usually down-regulate their body temperature from ～37℃ to only a few degrees. During the evolution, mammalian hibernators have inherited unique strategies to survive extreme conditions that may lead to disease or death in humans and other non-hibernators. Hibernating mammals can not only tolerant deep hypothermia, hypoxia and anoxia, but also protect them against osteoporosis, muscle atrophy, heart arrhythmia and ischemia-reperfusion injury. Finding the molecular and regulatory mechanisms underlying these adaptations will provide novel ideas for treating related human diseases.
机标关键词：
论文发表日期：2021-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 65-68 )
英文信息