Therapeutic potential of gasotransmitters for cold stress-related cardiovascular disease
Haijian Sun1
Xiaowei Nie2
Kangying Yu3
Jinsong Bian4
1.School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China2.Shenzhen Key Laboratory of Respiratory Diseases,Shenzhen People's Hospital(The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518055,China3.Nursing School of Wuxi Taihu University,Wuxi 214064,China4.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen 518055,China;National University of Singapore(Suzhou)Research Institute,Suzhou 215000,China
摘要：Growing evidence has shown that exposure to low ambient temperature poses a huge challenge to human health globally. Actually, cold stress is closely associated with a higher incidence of cardiovascular morbidity and mortality in winter or in cold regions. Cellular and molecular mechanisms underlying cardiovascular complications in response to cold exposure have yet to be fully clarified. Considering that cold exposure is an important risk of cardiovascular complications, it is necessary to clarify the molecular mechanism of cold stress-induced cardiovascular diseases and to develop effective intervention strategies. Hydrogen sulfide (H2S), nitric oxide (NO), and carbon monoxide (CO) are well-known gasotransmitters that are endogenously produced in many biological systems. Accumulating studies have demonstrated that these gasotransmitters play a critical role in a wide spectrum of physiological and/or pathophysiological processes by regulating numerous signaling pathways. These gas signal molecules are emerging as important players in cardiovascular homeostasis, and disruption of these gasotransmitters is critically implicated in cardiovascular anomalies, such as hypertension, atherosclerosis, myocardial ischemia, heart failure, and stroke. Also, evidence is emerging that H2S, NO, and CO may be involved in the pathologies of cold stress-induced cardiovascular ailments. In this review, we aim to highlight and discuss the recent advances towards the development of gasotransmitters-based therapeutics for cold stress-related cardiovascular pathogenesis. We believe that the effects of H2S, NO, and CO on cardiovascular regulation under cold environment will attract tremendous interest in the near future as they serve as novel regulators of cardiovascular biology in cold environment.
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论文发表日期：2022-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 10-24 )
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