Ticagrelor versus clopidogrel in East Asian patients with acute coronary syndrome: A meta-analysis
Meijiao He1
Yanxiang Zang1
Danghui Sun1
Jianqiang Li1
Guangzhong Liu1
Jing Shi1
Yue Li2
1.Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin Medical University,Harbin 150001,China.2.Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin Medical University,Harbin 150001,China.;Institute of Metabolic Disease,Heilongjiang Academy of Medical Science,Harbin 150001,China;Heilongjiang Key Laboratory for Metabolic Disorder&Cancer Related Cardiovascular Diseases,Harbin 150081,China
摘要：Objective: There exist conflicting data on the efficacy and safety of ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome (ACS). We performed a meta-analysis to evaluate whether ticagrelor or clopidogrel produces better outcomes for East Asian patients with ACS. Methods: We searched for randomized controlled trials reporting associations between ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome in PubMed, EMBASE, web of science and Cochrane central register of controlled trials. Results: Ten studies involving 3715 participants were qualified for our analysis. The major adverse cardiovascular events (MACE) were significantly decreased in patients with ticagrelor treatment compared to those with clopidogrel (risk ratio [RR]: 0.61; 95％ confidence interval [CI]: 0.38-0.98; P = 0.042). There was no significant difference in all-cause death (RR: 0.89; 95％ CI: 0.61-1.29; P = 0.540), cardiovascular death (RR: 0.86; 95％ CI: 0.58-1.27; P = 0.451), myocardial infarction (RR: 0.91; 95％ CI: 0.65-1.27; P = 0.575) and stroke (RR: 0.77; 95％ CI: 0.44-1.36; P = 0.372) between ticagrelor and clopidogrel. Ticagrelor was associated with a significantly higher risk of bleeding compared to clopidogrel (RR: 1.71; 95％ CI: 1.37-2.13; P = 0.000). Conclusion: The present meta-analysis demonstrates that ticagrelor reduced the incidence of MACE in ACS patients from East Asia compared with clopidogrel. However, it increased the risk of bleeding.
机标关键词：
论文发表日期：2022-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 30-40 )
英文信息