Challenges and improvement in management of neonates born to mothers with COVID-19 in China
Jie Yang1
Zhuxiao Ren2
Lingkong Zeng3
Shiwen Xia4
Lin Wang5
Jiayu Miao2
Zhe Zhao6
Chuanzhong Yang7
Xiuyong Cheng8
Huayan Zhang9
Yuanfang Zhu10
Li Liu11
Xirong Gao12
Bin Yi13
Zhenlang Lin14
Wei Liu15
Xiaoyu Zhou16
Benqing Wu17
Ling Chen15
Zhankui Li18
Xuefeng Zhang19
Wei Lu20
Lianhong Zhang21
Xiao Chen22
Xiaoyun Zhong23
Falin Xu24
Jinhui Wu25
Yong Ji26
Jiahua Pan27
Yanxiang Chen28
Carine Ronsmans29
Zhichun Feng6
1.Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou 510000, China;Department of Neonatology, Nanfang Hospital, Southern Medical University,Guangzhou 510000, China2.Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou 510000, China3.Department of Neonatology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science &Technology, Wuhan 430000, China4.Department of Neonatology, Hubei Women and Children Hospital, Wuhan 430000, China5.Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China6.Department of Neonatology, Seventh Medical Center, People's Liberation Army General Hospital, Beijing 100010, China7.Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518000, China8.Department of Neonatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China9.Division of Neonatology and Center for Newborn Care, Guangzhou Women and Children's Hospital, Guangzhou 510000, China;Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, United States10.Department of Obstetrics, Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen 518000, China11.Department of Neonatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China12.Department of Neonatology, Hunan Children's Hospital, Changsha, 410000, China13.Department of Neonatology, Gansu Provincial Maternal and Child Health Hospital, Lanzhou 730000, China14.Department of Neonatology, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China15.Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China16.Neonatal Medical Centre, Children's Hospital of Nanjing Medical University, Nanjing 210000, China17.Department of Neonatology, The University of Chinese Academy of Science-Shenzhen Hospital, Shenzhen 518000, China18.Department of Neonatology, Northwest Women and Children's Hospital, Xi'an 730000, China19.Department of Neonatology, The Fifth Medical Center, People's Liberation Army General Hospital, Beijing 100010, China20.Neonatal Intensive Care Unit, Yichang Central People's Hospital, First Clinical Medical College of China, Three Gorges University, Yichang 443000, China21.Department of Neonatology, Tianmen No.1 People's Hospital, Tianmen 433200, China22.Department of Neonatology, The First Affiliated Hospital of Nanchang University, Nanchang 330000, China23.Department of Neonatology, Chongqing Women and Children's Health Hospital, Chongqing 400001,China24.Department of Neonatology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China25.Department of Pediatrics, Jingmen Second People's Hospital, Jingmen 433200, China26.Department of Neonatal Intensive Care Unit, Shanxi Provincial Maternal and Child Health Hospital, Taiyuan 030001, China27.Department of Neonatology, The First Affiliated Hospital of the University of Science and Technology of China, Anhui Provincial Hospital, Hefei 230001, China28.Department of Neonatology, The First People's Hospital of Yinchuan, Yinchuan 750001, China29.Department of Infectious Disease Epidemiology, Faulty of Epidemiology and Population Health, London School of Hygiene and Tropical Mecidine, London WC1E 7HT, UK
摘要：Objective: China was the first country suffering from the SARS-CoV-2 pandemic and one of the countries with stringent mother-neonate isolation measure implemented. Now increasing evidence suggests that coronavirus disease 2019 (COVID-19) should not be taken as an indication for formula feeding or isolation of the infant from the mother.Methods: We conducted a retrospective cohort study in 44 hospitals from 14 provinces in China to investigate the management of neonates whose mothers have confirmed or suspected COVID-19. In addition, 65 members of Chinese Neonatologist Association (CNA) were invited to give their comments and suggestions on the clinical management guidelines for high-risk neonates. Results: There were 121 neonates born to 118 mothers suspected with COVID-19 including 42 mothers with SARS-CoV-2 positive results and 76 mothers with SARS-CoV-2 negative results. All neonates were born by caesarean section, isolated from their mothers immediately after birth and were formula-fed. Five neonates were positive for SARSCoV-2 at initial testing between 36 and 46 h after birth. Regarding the confusion on the clinical management guidelines, 58.78％ of the newborns were put into isolation, 32.22％ were subject to PCR tests, and 5.16％ and 2.75％ received breastfeeding and vaccination, respectively. Conclusion: The clinical symptoms of neonates born to mothers with confirmed SARS-CoV-2 were mild, though five neonates might have been infected in utero or during delivery. Given the favorable outcomes of neonates born to COVID-confirmed mothers, full isolation may not be warranted. Rather, separation of the mother and her newborn should be assessed on a case-by-case basis, considering local facilities and risk factors for adverse outcomes, such as prematurity and fetal distress.
机标关键词：covid-19managementchinawithbornchallengesimprovementmothers
论文发表日期：2022-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 94-102 )
英文信息