Nortriterpenoids from the fruit stalk of Schisandra chinensis (Turcz.) Baill.
Yan Liu1
Xiaohui Rong1
Yuanhang Chang2
Juan Pan1
Wei Guan1
Haixue Kuang1
Bingyou Yang1
1.Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, China2.Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China
摘要：Objective: The fruit stalk of Schisandra chinensis (Turcz.) Baill. (S. chinensis) has been found to contain bioactive components similar to the fruit of S. chinensis. Here, we report a recent discovery about new nortriterpenoids with a novel skeleton and anti-gastric cancer activity, which were isolated from the fruit stalk of S. chinensis.Methods: The chemical components of ethyl acetate extract from 70％ ethanol extract from S. chinensis fruit stalk were separated, purified, and identified by liquid chromatography methods (silica gel, ODS, HPLC) and extensive spectroscopic analyses (NMR, IR, UV, MS, CD). Results: Two new nortriterpenoids, schilancitrilactone M and 25-hydroxyl schindilactone D (1 and 2), along with ten known nortriterpenoids (3-12) were isolated from the fruit stalk of S. chinensis. The isolated compounds were tested for their cytotoxic activities against MGC-803 cells, and the results showed that compounds 6-8 possessed significant activities with IC50 of 9.01, 11.77, and 2.74 μmol/L, respectively.Conclusion: Twelve nortriterpenoids including two new compounds were isolated from the fruit stalk of S. chinensis for the first time. Among them, compounds 6-8 showed significant anti-gastric cancer activities. We postulated that the fruit stalk of S. chinensis could be used as an anti-gastric cancer drug.
机标关键词：triterpenoidsfrombaill.chinensisfruitschisandrastalkturcz.
论文发表日期：2022-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 103-108,中插1-中插10 )
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