Computation-aided novel epitope prediction by targeting spike protein's functional dynamics in Omicron
Bin Sun1
Yong Zhang2
Baofeng Yang3
1.Research Center for Pharmacoinformatics(The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China),Department of Medicinal Chemistry and Natural Medicine Chemistry,College of Pharmacy,Harbin Medical University,Harbin 150081,China2.Department of Pharmacology(The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China),College of Pharmacy,Harbin Medical University,Harbin 150081,China;Research Unit of Noninfectious Chronic Diseases in Frigid Zone,Chinese Academy of Medical Sciences,Harbin 150036,China3.Department of Pharmacology(The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China),College of Pharmacy,Harbin Medical University,Harbin 150081,China;Department of Pharmacology and Therapeutics,Melbourne School of Biomedical Sciences,Faculty of Medicine,Dentistry and Health Sciences University of Melbourne,Melbourne 3010,Australia;Research Unit of Noninfectious Chronic Diseases in Frigid Zone,Chinese Academy of Medical Sciences,Harbin 150036,China
摘要：1 The ever-growing crisis imposed by Omicron
The global corona virus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has lasted for more than 3 years and resulted in about 657 million infections and 6.6 million deaths as of date 05 January, 2023 ( The latest variant of concern (VoC), Omicron, is leading a new wave of infections globally[1]. Although small molecule inhibitors are emerging to show antiviral activities for SARS-CoV-2[2-3], only limited drugs have been approved (e.g., remdesivir and baricitinib). Vaccination remains the preferred protection method, however, extra vaccine dose is often required to effectively neutralize Omicron[4];especially for the continuous evolution SARS-CoV-2 variants by constant mutations, escape from neutralizing antibodies is still a major concern that challenges the effectiveness of existing vaccines[5]. This global public health crisis urgently demands developing effective antibodies against the Omicron.
机标关键词：predictiondynamicsproteinnovelaidedcomputationepitopefunctional
论文发表日期：2023-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1-4 )