Aminothiols exchange in coronavirus disease 2019
Fefelova Elena Viktorovna1
Karavaeva Tatyana Mikhailovna2
Parshina Anastasia Anatolyevna1
Ma Van De Vasilina Denisovna3
Tereshkov Pavel Petrovich4
1.Department of Pathological Physiology,Chita State Medical Academy,Chita 672090,Russia2.Department of Chemistry and Biochemistry,Chita State Medical Academy,Chita 672090,Russia3.Department of Faculty Therapy,Chita State Medical Academy,Chita 672090,Russia4.Laboratory of Experimental and Clinical Biochemistry and Immunology,Chita State Medical Academy,Chita 672090,Russia
摘要：Objective:Clinical manifestation of the inflammatory process in its relation to biochemical markers(total cysteine[Cys],cysteine-glycine[CysGly],glutathione[GSH],glutamate-cysteine[Glu-Cys],homocysteine[Hcy],the ratio of reduced to oxidized glutathione[GSH/GSSG],the ratio of reduced to oxidized cysteine[CySH/CySS],malondialdehyde-oxidized low-density lipoproteins[MDA-oxLDL])has been studied in patients with coronavirus disease 2019(COVID-19).Material and methods:48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our research.The participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6(IL-6).Results:All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6(by 54.6%).There was no comorbidity in patients with mild COVID-19(nasopharyngitis symptoms)and in healthy control subjects.50%of patients with lung damage had accompanying diseases.Alterations of aminoethyl metabolism were detected in COVID-19 patients:as reflected by the decreased levels of Cys,CysGly,and Glu-Cys and the increased levels of GSH as compared to the control group.Conclusion:Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation,specifically MDA-oxLDL.
机标关键词：exchangeaminothiolscoronavirusdisease
论文发表日期：2023-01-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 37-41 )
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