Association of point in range with β-cell function and insulin sensitivity of type 2 diabetes mellitus in cold areas
Yanan Ni1
Dan Liu2
Xiaona Zhang1
Hong Qiao1
1.Department of Endocrinology,NO.2 Affiliated Hospital of Harbin Medical University,Harbin 150081,China2.Department of Biostatistics,Harbin Medical University,Harbin 150086,China
摘要：Background and Objective:Self-monitoring of blood glucose(SMBG)is crucial for achieving a glycemic target and upholding blood glucose stability,both of which are the primary purpose of anti-diabetic treatments.However,the association between time in range(TIR),as assessed by SMBG,and β-cell insulin secretion as well as insulin sensitivity remains unexplored.Therefore,this study aims to investigate the connections between TIR,derived from SMBG,and indices representing β-cell functionality and insulin sensitivity.The primary objective of this study was to elucidate the relationship between short-term glycemic control(measured as points in range[PIR])and both β-cell function and insulin sensitivity.Methods:This cross-sectional study enrolled 472 hospitalized patients with type 2 diabetes mellitus(T2DM).To assess β-cell secretion capacity,we employed the insulin secretion-sensitivity index-2(ISSI-2)and(ΔC-peptide0-120/Δglucose0-120)× Matsuda index,while insulin sensitivity was evaluated using the Matsuda index and HOMA-IR.Since SMBG offers glucose data at specific point-in-time,we substituted TIR with PIR.According to clinical guidelines,values falling within the range of 3.9-10 mmol were considered"in range,"and the corresponding percentage was calculated as PIR.Results:We observed significant associations between higher PIR quartiles and increased ISSI-2,(ΔC-peptide0-120/Δglucose0-120)× Matsuda index,Matsuda index(increased)and HOMA-IR(decreased)(all P＜0.001).PIR exhibited positive correlations with log ISSI-2(r=0.361,P＜0.001),log(ΔC-peptide0-120/Δglucose0-120)× Matsuda index(r=0.482,P＜0.001),and log Matsuda index(r=0.178,P＜0.001)and negative correlations with log HOMA-IR(r=-0.288,P＜0.001).Furthermore,PIR emerged as an independent risk factor for log ISSI-2,log(ΔC-peptide0-120/Δglucose0-120)× Matsuda index,log Matsuda index,and log HOMA-IR.Conclusion:PIR can serve as a valuable tool for assessing β-cell function and insulin sensitivity.
机标关键词：associationinsulinpointfunctionareasrangecellcold
论文发表日期：2023-10-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 242-252,中插13 )
英文信息