Toll-like receptors 2 polymorphism is associated with psoriasis:A case-control study in the northern Chinese population
Siyu Hao1
Yu Zhang1
Anqi Yin1
Ying Lyu1
Nannan Tong1
Jiangtian Tian2
Yuzhen Li1
1.Department of Dermatology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China2.The Key Laboratory of Myocardial Ischemia,Chinese Ministry of Education,Harbin 150000,China;Department of Cardiology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China
摘要：Background:Psoriasis is a disease caused by genetics and immune system dysfunction,affecting the skin and joints.Toll-like receptors(TLRs)play an important role in triggering the innate immune response and controlling adaptive immunity.The role of TLR2 in the progression of psoriasis is not well understood.Methods:A case-control study was conducted on a northern Chinese Han population,consisting of psoriasis patients and healthy control subjects.Genotyping was performed using the tetra-primer amplification refractory mutation system-polymerase chain reaction(ARMS-PCR),and allele and genotype frequencies of four SNPs in TLR2 were analyzed in 270 psoriasis patients and 246 healthy controls.Results:FourTLR2 SNPs(rs11938228,rs4696480,rs3804099,rs5743699)were genotyped and found to be in linkage disequilibrium.The genotype distributions of rs11938228 and rs4696480 in two groups were in Hardy-Weinberg equilibrium and statistically significant except for the overdominance model.The haplotypes ATTC and ATCC were found to be protective against psoriasis.Conclusion:Our study found a correlation between TLR2 genetic variations and the likelihood of psoriasis in northern China.
机标关键词：case-controlpopulationtoll-likechinesenorthernstudywithassociated
论文发表日期：2024-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 96-101 )
英文信息