Initial effects of inflammation-related cytokines and signaling pathways on the pathogenesis of post-traumatic osteoarthritis
Peng-Fei Han
Zhi-Liang Zhang
Tao-Yu Chen
Rui-Peng Zhao
Rong Zhang
Xiao-Dong Li
Peng-Cui Li
Lei Wei
Zhi Lv
Xiao-Chun Wei
摘要：The main pathological change in post-traumatic osteoarthritis (PTOA) is cartilage degeneration,which is closely related to inflammation and oxidative stress.Inflammation can cause degeneration of articular cartilage.Cartilage degeneration can also stimulate the progression of inflammation.It has been found that inflammatory cytokines can participate in the pathological process of cartilage degeneration through multiple signaling pathways,mainly mitogen-activated protein kinase,nuclear transcription factor kappa B,and Wnt-β-catenin signal transduction pathways.This review aimed at exploring the relationship between PTOA and inflammation-related cytokines by introducing the role of proinflammatory cytokines in chondrocyte destruction and extracellular matrix degradation.
机标关键词：
资助基金：Shanxi Province Returned Overseas Students Research Funding Project (2016-118)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 91-96 )
英文信息