Study on the mechanism of nursing intervention based on environmental enrichment on cognitive function in ischemic stroke rats
Qing Wu1
Yang Li2
Pei-Pei Du3
Yan Chen3
1.Department of Pharmaceutical Engineering,Jiangsu Provincial Xuzhou Pharmaceutical Vocational College,Jiangsu 221000,China2.N6 Gynecology Ward,The Affiliated Hospital of Xuzhou Medical University,Jiangsu 221000,China3.Nursing Department,Jiangsu Provincial Xuzhou Pharmaceutical Vocational College,Jiangsu 221000,China
摘要：Objective:Investigating the effects and molecular mechanisms of nursing interventions based on environmental enrichment on cognitive function in ischemic stroke rats.
Methods:A total of 30 Sprague-Dawley(SD)rats belonging to the same batch were randomly divided into 3 groups(n=10)using a random number table:Sham Surgery Control Group(Sham),Ischemia-Reperfusion(I/R)Group,and Ischemia-Reperfusion Group with Environmental Enrichment Intervention(I/R+EEI).The expression levels of brain-derived neurotrophic factor(BDNF)protein in the hippocampus region were measured and compared among different groups.
Results:Compared with the Sham group,the I/R group showed significantly reduced learning and memory abilities,with notably lower BDNF levels(P＜0.05).Compared to the I/R group,the I/R+EEI group exhibited significantly improved learning and memory abilities as well as increased BDNF protein levels(P＜0.05).
Conclusions:Abnormal BDNF protein secretion may be the molecular mechanism of cognitive dysfunction due to hippocampal neuronal damage in ischemia-reperfusion,and modifying this neurotransmitter's secretion can effectively improve cognitive function in ischemia-reperfusion rats.
机标关键词：environmentalmechanismcognitivefunctionstrokestudyratsbased
论文发表日期：2025-09-20
在线出版日期：2025-10-13（本平台首次上网日期，不代表文献的发表时间）
页数：6( 311-316 )
英文信息