The effect of pre-transplant and transplant care on organ quality:a cross-sectional study
Marzieh Latifi1
Habib Rahban2
Elahe Pourhossein3
Mina Khalilzadeh4
Ahmad Amin5
Sanaz Dehghani6
1.Department of Public Health,School of Health and Safety,Shahid Beheshti University of Medical Sciences,Tehran,Iran2.Department of Cardiovascular Disease,Creighton University School of Medicine,St.Joseph Hospital and Medical Center,Phoenix,AZ,USA;Cardiovascular Research Foundation of Southern California,Beverly Hills,CA,USA3.Organ Procurement Unit,Sina Hospital,Tehran University of Medical Sciences,Tehran,Iran4.Experimental Medicine Research Center,Tehran University of Medical Sciences,Tehran,Iran5.Department of Cardiovascular Medicine Mayo Clinic,Rochester,MN,USA6.Organ Procurement Unit,Sina Hospital,Tehran University of Medical Sciences,Tehran,Iran;Iranian Tissue Bank & Research Center,Tehran University of Medical Sciences,Tehran,Iran
摘要：Objective:To determine the effect of management before and during transplantation on the quality of donated organs.Improvement of preservation methods in cases involving brain death will lead to more effective organ procurement.
Methods:Data were collected from the 226 brain death cases enrolled in the 12-month study period.All cases,patients with a Glasgow Coma Scale(GCS)score of 3 points,appropriate age,and having medical indications for organ donation,were considered to confirm the criteria of brain death.Transplant outcome data were obtained from the transplant centers.
Results:The age of the deceased ranged between 1 year and 68 years,with a mean±SD of 39.54±17.28 years.There was no significant difference between the quality of organs regarding blood group and cause of brain death(P＞0.05).However,there was a significant difference in the quality of organs regarding age,body mass index(BMI),and gender.There was a significant difference between the level of urea at admission time and procurement time(P＜0.001),as well as between creatinine level at admission time and procurement time(P＜0.001).There was also a significant difference between aspartate aminotransferase(AST)at admission time and procurement time(P＜0.001),and between alanine aminotransferase(ALT)at admission time and procurement time(P＜0.001).
Conclusions:Transplant outcomes using older donor livers and kidneys were comparable to those using younger or male donors.These findings provide further evidence that decision-making about organ quality is influenced by age and gender and emphasize the importance of transparency in organ acceptance practices.
机标关键词：qualitystudycarecross-sectionaleffectorganpre-transplant
论文发表日期：2025-09-20
在线出版日期：2025-10-13（本平台首次上网日期，不代表文献的发表时间）
页数：7( 375-381 )
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