Nursing management for ICANS of CAR T-cell therapy in B cell acute lymphoblastic leukemia
Hui-Yao Yang1
Jing-Jing Jin2
Qian-Qian Zhang2
Yan-Xia Liu2
Ying Wang2
Zhi-Xin Wang2
Jun-Ping Zhang2
Wen-Jun Xie2
1.Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China2.Leukemia Diagnosis and Treatment Center,State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300020,China;Tianjin Institutes of Health Science,Tianjin 301600,China
摘要：Objective:Immune effector cell-associated neurotoxic syndrome(ICANS)is one of the most concerning complications because of its life-threatening trait during chimeric antigen receptor(CAR)T-cell therapy and requires specialized management.We summarized the nursing procedures of CAR T-cell therapy for ICANS to provide some references for the standardized nursing care of ICANS.
Methods:Based on previous experience and literature research,the professional team developed nursing procedures for ICANS for patients receiving CAR T-cell therapy.
Results:The professional team developed step-by-step,sophisticated care procedures before,during,and after ICANS,including active communication and collaboration,knowledge updates,personalized nursing plans,advanced assessments,close monitoring of vital signs and laboratory tests,medication plans,timely and correct drug administration,dietary nursing interventions,safety care,nursing of other complications,follow-up of toxicities,and keeping an eye on the potential side effects.
Conclusions:ICANS is unique,with varying clinical symptoms and rapid progression.Timely and accurate treatment and care of patients is an effective way to manage ICANS.Professional and detailed procedures are required to guide nurses to manage patients' ICANS,so as to improve the safety of patients and the promotion of CAR T-cell therapy.
机标关键词：managementleukemiaacuteicanslymphoblasticnursingt-celltherapy
论文发表日期：2025-12-30
在线出版日期：2026-01-22（本平台首次上网日期，不代表文献的发表时间）
页数：8( 415-422 )
英文信息