Time-to-death and predictors of mortality among preterm neonates diagnosed with neonatal sepsis,Southwest Ethiopia,2022:prospective follow-up study
Belete Fenta Kebede1
Tsegaw Biyazin Tesfa2
Aynalem Yetwale Hiwot3
Yalemtsehay Dagnaw Genie4
Emebet Adugnaw Alem5
1.Department of Midwifery,College of Medicine and Health Sciences,Debre Markos University,Debre-Markos 269,Ethiopia2.School of Midwifery,Institute of Health,Jimma University,Jimma 378,Ethiopia3.Department of Midwifery,Woldia University,Woldia 400,Ethiopia4.Department of Pediatrics and Child Health Nursing,College of Medicine and Health Sciences,Debre-Markos University,Debre Markos 269,Ethiopia5.Department Public Health,College of Health Sciences,Mizan Tepi University,Tepi 260,Ethiopia
摘要：Objective:Neonatal sepsis is a critical pathology that particularly affects neonates,especially preterm and low birth weight neonates,with varying incidence according to the onset(early or late)of the disease.Although preterm neonatal mortality related to sepsis is high in Ethiopia and in the study area,limited studies have been conducted on the time-to-death and predictors of mortality among preterm neonates diagnosed with neonatal sepsis.Therefore,this study aimed to determine the time-to-death and predictors of mortality among preterm neonates with neonatal sepsis admitted to government hospitals in Southwest Ethiopia in 2022.
Methods:A prospective cohort study was conducted at the Southwest government hospitals between March 2021 and January 30,2022.The data were entered into Epi-data version 4.4.2.1 and exported to Stata version 14 for editing,cleaning,and analysis.The Cox proportional hazards(CPH)model was used to identify the predictors of mortality.
Results:In this study,out of 354 preterm neonates diagnosed with neonatal sepsis,121(34.18％)had died with an incidence rate of 59.8％(95％confidence interval[CI]:50-71.5)deaths per 1000 person-day-observations.The median survival time of preterm neonates diagnosed with neonatal sepsis was 15 days.The following factors were the predictors of mortality among preterm neonates diagnosed with neonatal sepsis:(1)the neonate's mother did not have antenatal care(ANC)follow-up(adjusted hazard ratio[AHR]2.5[95％CI:1.3-4.84]);(2)the neonates had an APGAR score＜7(5th-minute activity,pulse,grimace,appearance,and respiration)(AHR 1.5[95％CI:1.29-3.46]);(3)and they had comorbidities such as respiratory distress syndrome(RDS)(AHR 1.50[95％CI:1.13-2.31])and jaundice(AHR 1.89[95％CI:1.26-2.84]).
Conclusions:In this study,preterm neonates diagnosed with neonatal sepsis showed a higher incidence of mortality compared with other national and local studies.The median survival time of neonates was 15 days.Born from mothers who did not have ANC follow-up,5th-minute APGAR score＜7,and comorbidities such as RDS and jaundice were independent predictors of mortality among preterm neonates diagnosed with neonatal sepsis.Therefore,healthcare providers and other stakeholders should consider prompt and timely diagnosis and therapeutic interventions to preterm neonates with neonatal sepsis.
机标关键词：studywithamongdiagnosedethiopiafollow-upmortalityneonatal
论文发表日期：2025-12-30
在线出版日期：2026-01-22（本平台首次上网日期，不代表文献的发表时间）
页数：11( 477-487 )
英文信息