Relationship of Plasma IL-6 to the Metabolic Measures associated with Insulin Resistance due to Adiposity
Ryoyu Takeda1
Yoshihiro Takayama1
Yuji Ito1
Takaharu Masunaga1
Takahiro Zenda1
Satoshi Asaka1
Hisanori Oiwake1
Kimihide Shinozaki1
Yoshiyu Takeda2
Isamu Miyamori3
吴平生4
1.Department of Internal Medicine, KKR-Hokuriku Hospital, Kanazawa, Japan2.Department of Medicine, Kanazawa University, Kanazawa, Japan3.Fukui Medical University, Fukui, Japan4.Nang Fang Hospital, Guangzhou, P R China
摘要：Objectives To elucidate the relationship of plasma interleukin-6 (IL-6) to the metabolic measures associated with insulin resistance (IR) due to adiposity. Methods For a cross-sectional study, eighty normotensive men with and without obesity were enrolled consecutively in our health examination center. Fasting blood glucose (FBG), fasting plasma immunoreactive insulin (FIRI), HOMA-R (Homeostasis Model Assessment Insulin Resistance Index), plasma lipids (cholesterol, triglyceride, high density lipoprotein cholesterol), cortisol, dehydroepiandrosterone-sulfate (DHEA-S), interleukin-6 and C-reactive protein(CRP) were measured. Results Plasma levels of FIRI, triglyceride (TG), DHEA-S,CRP and HOMA-R were significantly higher in obese group with BMI over 25 than non-obese group,whereas HDL-C was significantly lower in obese group. BMI was positively correlated with FIRI, TG,hsCRP and HOMA-R, whereas negatively with HDLC. BMI was positively correlated with plasma DHEAS levels but not with cortisol. Plasma levels of IL-6 were positively correlated with FIRI, TG, CRP and HOMA-R but in a multiple regression analysis with IL-6, only HOMA-R and TG remained explainable variables. Conclusions Each of commonly used measures of inflammatory reaction, CRP and IL-6, showed a significantly positive correlation with either FIRI or HOMA-R, suggesting associations between subclinical inflammation and obesity as the risk of type 2 diabetes mellitus.
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分类号：R54(心脏、血管（循环系）疾病)
论文发表日期：2004-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 5-10 )
英文信息