Analysis on Homocysteine's Risk to Atherosclerosis and Its Correlations with Serum Lipids
李河
郭兰
肖敏
陈铁峰
吴书林
余细勇
石美铃
董太明
刘小清
黄平
李义和
1.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China2.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China3.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China4.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China5.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China6.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China7.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China8.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China9.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China10.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China11.Guangdong Provincial People's Hospital, Guangzhou 510080, P R China
摘要：Objectives To explore the homocysteine's risk to atherosclerosis and its correlations with serum lipids TG,TG and HDL-C. Methods With a cross sectional study, 490 subjects (aged 41-86 yrs, male 420 and female 70) were surveyed in 1999 in Guangdong Province, China. The main research variables were homocysteine (Hcy) and the serum lipids total cholesterol (TC), triglyceride (TG),high-density lipoprotein cholesterol(HDL-C). Results Hcy was a possible risk factor resulting in atherosclerosis (OR=l.15, 0.05 ＜P ＜0.10, n=108) with Logistic regression analysis. There is no correlation or much lower degree correlation between Hey and the serum lipids group of TC, TG, HDL-C. The canonical correlation coefficient between V1 and W1 was R1,Can =0.12(0.05＜P＜0.10, n=490, V1=Hcy, W1= - 0.9446 * TC + 0.1588 * TG + 0.6009 * HDL-C). Conclusions It is possible that Hcy is a risk factor to atherosclerosis and is independent of serum lipids group or has much lower correlation with it. It is necessary to do more research to explore the risk degree of Hcy inducing atherosclerosis and whether are there are bigger correlations or higher independence between Hcy and other risk factors during the progress of atherosclerosis.
机标关键词：
分类号：R543(心脏、血管（循环系）疾病)
论文发表日期：2004-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 13-16 )
英文信息