Gene Expression Analysis of Human Vascular Endothelial Cells Treated by Ouabain in Pathological Concentration
任延平
吕卓人
1.Medical School of Xi'an Jiaotong University, Xi'an 710061, P R China2.Medical School of Xi'an Jiaotong University, Xi'an 710061, P R China
摘要：Objectives To study the gene expression of human vascular endothelial cells (HUVEC) treated by ouabain in pathological concentration. Methods The response of endothelial cells to ouabain of 1.8 nmol/L was explored with a complementary DNA microarray representing 8 464 different human genes. Results The results of mRNA profiles analysis indicated that 129 of the genes were differently expressed, 26 were upregulated. Conclusions The pathological role of ouabain on HUVEC may be involved in the controlling of DNA transcription、protein translation、 metabolism and signal transduction.
机标关键词：
分类号：R54(心脏、血管（循环系）疾病)
论文发表日期：2004-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 25-28 )
英文信息