The Association between Myeloperoxidase-463G/A Gene Polymorphism and Coronary Artery Disease
Shili Wu
Hui Li
Yuli Huang
Hongju Wang
Heng Zhang
Zongming Bao
摘要：Objectives To study the relationship between myeloperoxidase (MPO)-463G/A polymorphisms and susceptibility to coronary artery disease (CAD) in Han people of north Anhui province. Methods The case group consisted of 79patients who had all angiographically proven CAD were retrospectively studied. Used polymerase chain reaction-restric-tion fragment length polymorphism (PCR-RFLP) methods to decide the genotype of all the patients. Results The fre-quency of AA homozygotic type in Han people of Anhui province was 1.4%. The risk of CAD for person carrying at least one A allele genotype (GA and AA) was 0. 37 times of GG genotype. The severity of coronary artery stenosis in CAD patients carrying at least one A allele genotype was 0. 197 times of GG genotype (P < 0. 05). Conclusions The frequency of AA homozygotic type and MPO-463G/A polymorphism in Han people of Anhui province influenced the risk of CAD. A allele had protective function in CAD.
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分类号：R5(内科学)
论文发表日期：2008-05-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 116-119 )
英文信息