Carvedilol Inhibits Na+ Current in Rat Ventricular Myocytes
Chun-yu DENG
Su-juan KUANG
Qing-shan GENG
Wei-min QIAN
Shu-lin WU
Zhi-xin SHAN
Qiu-xiong LIN
Min YANG
Xi-yong YU
Shu-guang LIN
摘要：Objectives The effects of carvedilol on sodium current (ⅠNa) were investigated in isolated adult rat ventricular myo-cytes. Methods Single ventricular myocytes were enzymatically dissociated. ⅠNa was recorded by whole-cell patch-clamp recording technique. Results 1. Carvedilol reversibly inhibited ⅠNa in a concentration-dependent manner, with an IC50of(6.35±0.40)mol·L-1.2.This inhibition was voltage-and frequency-dependernt.3.Carvedilol decreased the peak of the Ⅰ-Ⅴ relationship curve at - 35 mV from (17. 31 ± 1.68) pA/pF to (6. 58 + 1.35) pA/pF, but did not change active potential, peak potential and the reverse potential significantly. 4. The steady-state inactivation curve of ⅠNa was shifted to more negative potentials. Conclusions Carvedilol inhibits ⅠNa in adult rat ventricular myocytes by mechanisms involving preferential interaction with the inactivated state of sodium channel.
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分类号：R5(内科学)
论文发表日期：2009-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 85-89 )
英文信息