Cardiac Connexin 43 and Ischemic Cardioprotection
Jin-yi LI
Guo-qiang ZHONG
Yan HE
Yun LING
摘要：The connexin 43 (Cx43) proteins, which is the predominant protein that can form gap junctions and non-junctional hemichannels in ventricular myocardium, are central to the cardioprotection afforded by ischemic precondi-tioning (IP) and maybe ischemic postconditioning (PC) too. Recent studies showed that recruitment of Cx43 to the mitochondria in IP might play a role in the production of reactive oxygen species (ROS) that mediates IP. The localiza-tion of Cx43 at mitochondria appears to be important for the achieved cardioprotection and opens a new door for us to reveal the exact mechanisms of ischemia/reperfusion (I/R) injury and cardioprotection, and it might be new targets of pharmacological modulator to achieved cardioprotection.
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分类号：R5(内科学)
论文发表日期：2009-04-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 97-105 )
英文信息