Hyperuricemia and severity of coronary artery disease in patients undergoing selective percutaneous coronary intervention

LIU Yong; CHEN Li-ling; TAN Ning; ZHOU Ying-ling; HE Peng-cheng; XIE Nian-jin; LUO Jian-fang; CHEN Jin; CHEN Ji-yan

摘要：Background Hyperuricemia as an independent predictor for presence of coronary artery disease (CAD)has been studied insufficiently. In this study, we evaluated the predictive value of hyperurieemia for the severity of coronary artery disease. Methods A total of 683 patients undergoing elective percutaneous coronary intervention (PCI) were prospectively observed and were divided into two groups (hyperuricemie group, n = 216, and normouricemic group, n = 467). Hyperuricemia (HUA) was defined as an serum uric acid level > 7 mg/dL in males and > 6 mg/dL in fe-males. Severe CAD was defined as triple-vessel disease or left main disease. Results One hundred and eighteen (55%) severe CAD occurred in the hyperuricemic group and 211(45%) in the normouricemic group (P = 0.02). The median uric acid levels of the severe CAD patients were significantly higher than secondary CAD (single vessel disease or two-vessel disease) patients (379 ± 111 vs 360 ± 105, P = 0.02). Multivariate logistic regression analysis, after ad-justing for potential confounding factors, showed that HUA was an independent risk factor of coronary artery disease (odds radio = 1.63, 95% confidence interval, 1.02-2.61, P = 0.040). Moiety of in-hospital complications such as a cute heart failure ( 17.6% vs. 6.2%, P < 0.001), hypotension (3.8%, vs. 1.3%, P = 0.04), contrast induced nephropa-thy (CIN) (7.4% vs. 1.3%, P < 0.001) after PCI, were significantly higher in hyperuricemic groups. Conclusions Hyperuricemia was an independent predictor for severe coronary artery disease (triple-vessel disease or left main dis-ease).