Relation between pre-procedural glucose levels and incidence of major adverse cardiac events in chronic kidney disease patients without established diabetes undergoing percutaneous coronary intervention
MAI Guo-hui
LIU Yong
QIN Xue-qing
MEI Bai-qiang
OU Zhan-peng
TAN Ning
摘要：Background It is well known that there was a significant link between preprocedural blood glucose levels and short-term and long-term adverse outcomes in patients undergoing elective PCI.However,the role of preprocedural blood glucose levels as a predictor of adverse events in CKD patients who underwent PCI out of established diabetes has yet to be identified.Methods In our study,we conducted a prospective study of 331 acute coronary syndrome (ACS) patients with CKD who underwent PCI out of established diabetes.Patients were divided into two groups based on pre-procedural glucose levels (hypoglycemia ＜ 7.0 mmol/L; hyperglycemia≥ 7.0 mmol/L).All patients were followed up prospectively for major adverse cardiovascular events (MACEs)and mortality for 6 months.Results In our cohort,hyperglycemia patients reported a higher incidence of inhospital mortality than hypoglycemia patients (7.5％ vs.0％,P ＜ 0.001).Hyperglycemia patients reported a significantly higher rate of 6-month MACEs (10％ vs.2.4％,P =0.007),all cause mortality (7.5％ vs.1.6％,P =0.015),and cardiovascular mortality (6.2％vs 1.6％,P =0.041) compared with hypoglycemia patients with pre-procedural glucose levels ＜ 7.0 mmol/L.Multivariate analysis disclosed that a pre-procedural glucose level ≥7.0 mmol/L was a significant independent predictor of MACEs (OR =2.53,95％ CI 1.68-17.15,P =0.004),all cause mortality(OR =4.6,95％ CI 1.10-18.84,P =0.036),and cardiovascular mortality(OR =6.2,95％ CI 1.53-24.94,P =0.011) at 6 months in patients after PCI.Conclusion The study suggested that pre-procedural glucose levels are associated with short-term cardiovascular outcome CKD patients who underwent PCI without established diabetes in the setting of ACS.
机标关键词：
分类号：R541.4(心脏、血管（循环系）疾病)R587.2(内分泌腺疾病及代谢病)
论文发表日期：2011-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息