Contrast-induced nephropathy after a second percutaneous coronary intervention in patients with chronic kidney disease
Qin Xue-qing
LIU Yong
TAN Ning
Gan Fu-dong
ZHOU Ying-ling
CHEN Yu-yi
CHEN Ji-yan
CHEN Li-ling
Yang Da-hao
摘要：Background Data are limited regarding the risk of contrast-induced nephropathy (CIN) for patients after the second contrast exposure.Objective To examine the risk of CIN after the second contrast exposure in patients of acute coronary syndrome (ACS) with chronic kidney disease (CKD).Methods Patients of ACS scheduled for a second elective PCI.Patients were required to have an estimated creatinine clearance (CrC1) between 15 and 60 ml/min.The value of serum creatinin (sCr) prior to the second contrast exposure must not be ≥ 25％ or ≥ 88.4 μmol/L compared to baseline.CIN was defined as an increase of sCr ≥ 25％ from baseline within 48-72h after the second contrast exposure.The primary end-point was risk of developing CIN.Results Thirty-nine patients completed the study.The average of interval between contrast exposures was 116 ± 64 h,contrast volume was 266 ± 100 mL and length of hospitalization was 8.3 ± 4.7 days.The incidence of CIN in the overall study population was 10.3％.There was not change significantly in average sCr and CrC1 after the second contrast exposure (sCr 1.52 ± 0.62 vs.1.54 ± 0.60 mg/dL baseline,P =0.75; CrC1 (40.68 ± 14.46 vs.39.16 ± 12.10mL/min baseline,P =0.26).None of the patient was death in 30 days.One (2.6％) of the patients who developed CIN required dialysis in-hospital.Conclusion Our findings suggest that patients with prior renal dysfunction are not increased risk of developing CIN after the second contrast exposure.This cohort may be benefit from sufficient prophylaxis.
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分类号：R541.4(心脏、血管（循环系）疾病)R692(泌尿科学（泌尿生殖系疾病）)
论文发表日期：2011-10-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息