Flavonoids from rape bee pollen on the clinical effects of antioxidant activity

BAO Yan-jiang; GUO Xue-wei; ZHOU Xiao-feng; LU Ting; YUAN Yu-liang; LIU Su-po; MA Li; WANG Hao; LI Ming; HONG Zhan-jiang; WANG Xiu-rong; GUO Mao-ling; WANG Zhu-feng

摘要：Background Flavonoids from fruits, vegetables and plants have been widely studied on their effects of improving lipidemia,anti-inflammation,anti-platelet aggregation and anti-oxidative activities.However,we don't know if flavonoids from rape bee pollen have the same effects in patients with dyslipidemia (DL),type 2diabetes mellitus(T2DM),and cerebral infarction(CI).Methods The study involved with patients selected and divided into 4 groups,30 cases of DL,of T2DM,of CI and health control (HC) for each.Forty mg flavonoids from rape bee pollen administrated orally twice a day for two months.Blood sugar (BG),total cholesterol (TC),triglyceride (TG),high density lipoprotein-cholesterol (HDL-C),low density lipoprotein-cholesterol (LDL-C),white blood-cell counts (WBC),platelet counts (PLT),high-sensitivity C-reactive protein (hsCRP) and malondialdehyde (MDA) were analyzed in four groups before and after taking flavonoids for two months.Results ( 1 ) Basic levels of TC,BG,WBC,PLT and hsCRP in groups of T2DM,CI,and TG and MDA in groups of DL,T2DM and CI were significantly higher than those in HC (P ＜ 0.05-0.001 ).(2) The levels of TG,WBC,PLT, hsCRP and MDA were significantly decreased, while HDL-C was remarkably increased after taking flavonoids for two months (P ＜ 0.05-0.001 ) in group of DL,T2MD,and CI.These indexes were not different in the group of HC after taking flavonoids (P ＞ 0.05).Conclusions The results could indicate metabolic disturbance,inflammation,and high oxidative stress in patients with dyslipidemisa,type 2 diabetes mellitus,and cerebral infarction.The flavonoids from rape bee pollen may have effects of antioxidant activity,improving lipids,and anti-inflammation on these patients.