Changes of insulin resistance and plasma levels of Ang Ⅱ and NO in normal offspring with a family history of es sential hypertension
JIA Hui-hui
WU Na
FU Zeng-pan
摘要：Backgound Essential hypertension (EH) is a polygenic inheritable disease,generally known as a combined result of genetic and environmental elements.It is possible that IR、Angiotensin Ⅱ (Ang Ⅱ ) and NO play important roles in the pathogenesis of EH. Methods Sixty normal subjects with a family history of EH, aged 30 to 40 years old, were recruited and randomized into two groups: 30 with one parent and 30 with both parents with EH, and 30 subjects without family history of EH as controls. The plasma level of NO was determined by electrophotometer while the plasma level of fast insulin (FINS) and Ang Ⅱ were determined by radioimmunoassay,and insulin resistance index (IRI) was calculated.Results ① The plasma levels of FINS,Ang Ⅱ,NO increased significantly in study groups compared with those in the control group(P ＜ 0.01),while there were no differences in the levels of AngⅡ,NO between the two study groups (P ＞ 0.05).② The plasma level of AngⅡ were positively correlated with that of NO (r =0.378, P ＜ 0.01 ). Conclusions The higher levels of IR and plasma AngⅡ and NO exist before the development of EH in normal offspring with a family history of EH, and maybe they are initial agents in the pathogenesis of EH. It indicates that the people with IR and high levels of plasma Ang Ⅱ and NO with a family history of EH are at higher risk to develop EH.
机标关键词：
分类号：R544.1(心脏、血管（循环系）疾病)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息