Protective effect of Xuezhikang capsules in rats with acute myocardial ischemia reperfusion injury

ZHANG Xue-juan; SONG Li; TENG Lei; PING Li-feng

摘要：Background Recent researches have found that stains can improve acute myocardial ischemia reperfusion injury which is achieved by inhibiting inflammatory reaction. Xuezhikang is extracted from red rice, a tailormade Chinese crude drug. Main component of Xuezhikang that can inhibit blood-fat is statins. Methods Forty healthy SD rats (half male and half female,200 g or so) were randomly divided into four groups:A:normal control; B:sham operation; C:MIR group; D:Xuezhikang group.The acute myocardial ischemia reperfusion injury model was produced.Infarct sizes,MYO,CK-MB,cTnI,IL-10 and IL-18 were detected after reperfusion.Results Compared with C and D group, in A and B group, infarct size were increased significantly (P ＜0.01),the level of serum MYO,CK-MB,cTnI were increased significantly (P ＜ 0.01),the level of IL-10 were decreased significantly (P ＜ 0.01) and IL-18,CRP were increased significantly (P ＜ 0.01).Compared with C group,infarct size were decreased significantly (P ＜ 0.05),the level of serum MYO,CK-MB and cTnI were increased significantly (P ＜ 0.05),the level of IL-10 were increased significantly (P ＜ 0.05) and IL-18 were decreased significantly (P ＜ 0.05). The level of IL-10 and IL-18 were no difference between A and B group.Conclusion The application of Xuezhikang capsules on rats before the operation of myocardial ischemia reperfusion can lessen inflammatory reaction and reduce infarct sizes and protect acute myocardial ischemia reperfusion.