Effect of n-3 PUFAs on arterial stiffness in patients with cardiovascular disease
LI Lin
ZHANG Yan-jun
HE Peng-cheng
MA Wen-jun
LI Yuan-hong
摘要：Background Fish oil,rich in long-chain n-3 PUFAs,EPA and DHA,are known to reduce various risk factors for CAD1-3.However,conclusive regarding the benefits of n-3 PUFAs on arterial stiffness,a risk factor for CAD,has not yet been established.Methods In the placebo-controlled,single-blind,prospective study,60 subjects were randomly allocated to consume daily nutritional supplement of 3 gram capsules containing either placebo (soybean oil) or fish oil,EPA (540 mg) + DHA (360 mg) for 12 weeks.Anthropometry,pulse wave velocity (PWV) and polyunsaturated fatty acid were measured and compared before and after study therapy.Results After study therapy,PWV reduced significantly in the fish oil group compared with the placebo group (-8 + 18 cm/s vs 39 ± 19 cm/s,P＜ 0.05).Conclusions Fish oil shows beneficial effect on improving arterial stiffness in patients with coronary disease.[S Chin J Cardiol2012; 13(2):80-87]
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分类号：R54(心脏、血管（循环系）疾病)
论文发表日期：2012-07-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息